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        "title": "Market survey\/ procurement of two UHPLC-HRMS\/MS (ultra-high performance liquid chromatography - high resolution tandem mass spectrometer) and maintenance contracts for the devices",
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                "",
                "LC",
                "o UHPLC with maximum system pressure of at least 600 bar",
                "o Optionally biocompatibility. Wetted parts made of other than stainless steel",
                "o Column oven with capacity of at least one analytical column (200 mm) and one precolumn (50 mm)",
                "o Autosampler, which can be cooled down to 7\u00b0C \u00b1 2\u00b0C",
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                "o Mass accuracy <3ppm",
                "o Possibility to perform top-down analysis of proteins",
                "o Possibility to analyse and quantitate small molecules and peptides",
                "o Possibility to perform MS\/MS analysis in a quadrupole based collision cell",
                "o Dynamic range > 1000",
                "o Data analysis software (can be several) that enables:",
                "\uf0a7 Spectral library and database searches for small molecules",
                "\uf0a7 Quantitation of small molecules",
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                "\uf0a7 Protein identification based on deconvolution of intact protein data and MS2 data and search against sequence database including intact protein mass information (top-down)",
                "\uf0a7 Ideally combining previous two within a single piece of software",
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            "The current procurement concerns two UHPLC-HRMS\/MS systems. The one will replace current UHPLC-HRMS\/MS system (Orbitrap Elite) used in analysis of controlled substances and the other will be set up for analysis of food products.",
            "",
            "The former system will be used for analysis of illegally imported substances like medicines, doping substances, illegal drugs, new psychoactive substances (NPSs), illegal chemicals and drug precursors. Data acquired with the system together with data from nuclear magnetic resonance (NMR) analysis will enable determination of detailed chemical structure of NPSs. For the system to be able to determine chemical structure in detail, it is essential that the system enables good chromatographic resolution, high mass spectrometric resolution and high mass accuracy both in MS and MS\/MS. Essential part of analysis of aforementioned substances is dedicated software, which allows efficient and accurate analysis of LC-MS data. The system will be used in screening of aforementioned substances in cases where data acquired with other dedicated instruments is insufficient. For example, psilocybin mushrooms, biologicals and certain doping substances will be analysed with this system only. Analysis of biologicals and biological molecules requires high resolution and good mass accuracy, because for example identification of proteins and peptides is based on their accurate mass and amino acid sequence. Amino acid sequence on the other hand can be deduced from fragmentation data of either intact molecule or peptides produced by enzymatic digestion of a protein.",
            "",
            "The latter system will be used in analysis of food products. Primary focus of analyses will be on pesticides in addition to other contaminants found in plant based food products. While with current system used for the purpose, the number of different pesticides that can be analysed in one run is limited to approximately 250, the new UHPLC-HRMS\/MS system will enable determination of virtually unlimited number of compounds. This is especially beneficial for analysis of organic products and products originating outside the customs territory of the EU as they may be applied with uncommon or even unexpected pesticides or substances.",
            "",
            "The new UHPLC-HRMS\/MS system will increase Finnish Customs Laboratory\u2019s overall ability to detect food fraud. Technology allows recognition of substance profiles, which would indicate dilution of a product or replacement of an ingredient. Because the technology allows measurement of molecular profile of entire product, it is possible to return to previously acquired data to detect changes in profiles and in that way track down possible introduction of harmful substances within a product.",
            "",
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            "This notification is a market survey. ",
            "",
            "The procuring entity surveys the market and potential suppliers.",
            "",
            "No tenders are requested with this market survey.",
            "",
            "Responding or not responding to this market survey does not prevent participation in a possible tendering procedure.",
            "",
            "Answering or not answering this market survey notice does not prevent participation in a possible tender.",
            "",
            "Suppliers are not bound by this market survey. ",
            "",
            "Suppliers do not receive compensation for participating in this market survey.",
            "",
            "The information provided in this notification is preliminary and may change as the preparation progresses.",
            "",
            "The contracting entity requests material about the latest UHPLC-HRMS\/MS devices that are best suited for the device described in this notification.",
            "",
            "Sent the requested materials by 2 May 2023 to the following address: [email protected] and [email protected]. ",
            "",
            "The following heading should be used in the message: \u2018Market survey\/ UHPLC-HRMS\/MS.",
            "",
            "In June 2023, draft materials for the competitive tendering will be sent for comments (so-called technical dialogue), to those who sent materials.",
            "",
            "The descriptions presented in this notification and the estimated publication date of the procurement notice are indicative and only preliminary information, which does not bind the procuring entity. ",
            "",
            "The procuring entity hopes to receive answers to the following additional questions (you can answer in Finnish or English): ",
            "",
            "\u2022 What levels of maintenance do you offer? ",
            "\u2022 What are the estimated prices for the maintenance levels? ",
            "\u2022 What is your estimated delivery time for the device in weeks?",
            "\u2022 What software is required for the applications, and their prices?",
            "\u2022 What does the full maintenance contract include?",
            "\u2022 What are your maintenance response times?",
            "\u2022 Is the purchase price per unit of two identical HRMS devices lower than for one such device?",
            "\u2022 Do you have the possibility to deliver a demo license for the data processing software to the Customs Laboratory? What is the delivery schedule? How is the demo license installed?",
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            "",
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